From The Portal Wiki

"Defragilization" is the process of making something less fragile or more resilient. It may involve actions or strategies aimed at strengthening systems, structures, or entities to better withstand stress, uncertainty, or disruption. The prefix "de-" suggests a reversal or removal of fragility, indicating an intentional effort to enhance robustness or durability. In essence, defragilization could involve measures to increase stability, adaptability, and overall toughness in various contexts.