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C. elegans: Difference between revisions
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''The worm and model organism, [[ | ''The worm and model organism, [[C. elegans]], deserves your attention, no matter who you are, or what you do for a living.'' | ||
-'''Eric Weinstein''' in his essay, [https://theportal.group/34-the-importance-of-taste/ The Importance of Taste] | -'''Eric Weinstein''' in his essay, [https://theportal.group/34-the-importance-of-taste/ The Importance of Taste] | ||
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''So it's this worm that was chosen by this guy, [[Sydney Brenner]], who just died. And it's a shame because he would have been a great podcast guest, just, like, one of the most brilliant biologists that we didn't focus on. And he said, "You know what, we're missing a species that we can completely describe. Soup to Nuts. Here's the one that's about the simplest thing with a brain. It's only got 1000 cells. And 300 of those cells make up a very primitive neural system. And we're going to track where every goddamn cell—", like, bring up—Jamie, if I could ask you, sir, to bring up the cell lineage diagram for C. elegans. This will be the first of two images. Well, that is a complete map of how one fertilized egg becomes a tiny microscopic worm for every possible division.'' | ''So it's this worm that was chosen by this guy, [[Sydney Brenner]], who just died. And it's a shame because he would have been a great podcast guest, just, like, one of the most brilliant biologists that we didn't focus on. And he said, "You know what, we're missing a species that we can completely describe. Soup to Nuts. Here's the one that's about the simplest thing with a brain. It's only got 1000 cells. And 300 of those cells make up a very primitive neural system. And we're going to track where every goddamn cell—", like, bring up—Jamie, if I could ask you, sir, to bring up the cell lineage diagram for [[C. elegans]]. This will be the first of two images. Well, that is a complete map of how one fertilized egg becomes a tiny microscopic worm for every possible division.'' | ||
''Right now, here's the thing. Everyone in biology knows how cool this thing is. And very few people, not enough people outside of biology, know that we have completely mapped how one cell—like if you're 30 trillion cells around. It's too big to write a diagram. It's only possible because they're only 1000 cells. And this thing has locomotion. It has sexual reproduction. You know, it eats. So, you're looking at the architectural plans for an actual organism.'' | ''Right now, here's the thing. Everyone in biology knows how cool this thing is. And very few people, not enough people outside of biology, know that we have completely mapped how one cell—like if you're 30 trillion cells around. It's too big to write a diagram. It's only possible because they're only 1000 cells. And this thing has locomotion. It has sexual reproduction. You know, it eats. So, you're looking at the architectural plans for an actual organism.'' | ||
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|usernameurl=https://x.com/EricRWeinstein | |usernameurl=https://x.com/EricRWeinstein | ||
|username=EricRWeinstein | |username=EricRWeinstein | ||
|content=1st: Fly over C.Elegans (!!) http://bit.ly/ElegFO</br> | |content=1st: Fly over [[C. elegans|C.Elegans]] (!!) http://bit.ly/ElegFO</br> | ||
2nd: Think about 1000 cell lineage.</br> | 2nd: Think about 1000 cell lineage.</br> | ||
3rd: Buy mug http://bit.ly/WormMG</br> | 3rd: Buy mug http://bit.ly/WormMG</br> | ||
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|usernameurl=https://x.com/EricRWeinstein | |usernameurl=https://x.com/EricRWeinstein | ||
|username=EricRWeinstein | |username=EricRWeinstein | ||
|content=Tweet explanation request for @yaserhelmy. Everyone needs to know C Elegans, not just biologists. About 1000 cells / 300 neurons. | |content=Tweet explanation request for @yaserhelmy. Everyone needs to know [[C. elegans|C Elegans]], not just biologists. About 1000 cells / 300 neurons. | ||
|timestamp=11:52 PM · Dec 23, 2009 | |timestamp=11:52 PM · Dec 23, 2009 | ||
}} | }} | ||
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|usernameurl=https://x.com/EricRWeinstein | |usernameurl=https://x.com/EricRWeinstein | ||
|username=EricRWeinstein | |username=EricRWeinstein | ||
|content=So long and thanks for all the worms. | |content=So long and thanks for all the [[C. elegans|worms]]. | ||
RIP to the towering figure of [[Sydney Brenner]]. If you don’t believe in the great man theory of science it’s no biggfie. But for the rest of us, he was VAL in the RNA tie club. One of the only living scientists I was determined to meet. | RIP to the towering figure of [[Sydney Brenner]]. If you don’t believe in the great man theory of science it’s no biggfie. But for the rest of us, he was VAL in the RNA tie club. One of the only living scientists I was determined to meet. | ||
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|usernameurl=https://x.com/EricRWeinstein | |usernameurl=https://x.com/EricRWeinstein | ||
|username=EricRWeinstein | |username=EricRWeinstein | ||
|content=@DavidDeutschOxf @rickygervais Further, while our cell counts may be in the 10s of trillions, our number of distinct adult cell types is on the same order of magnitude as C Elegans. Suggesting scale and layout as the main issues within the “Lego” of our cellular building blocks. I think @rickygervais is right. | |content=@DavidDeutschOxf @rickygervais Further, while our cell counts may be in the 10s of trillions, our number of distinct adult cell types is on the same order of magnitude as [[C. elegans|C Elegans]]. Suggesting scale and layout as the main issues within the “Lego” of our cellular building blocks. I think @rickygervais is right. | ||
|timestamp=5:26 PM · Feb 26, 2021 | |timestamp=5:26 PM · Feb 26, 2021 | ||
}} | }} | ||
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• Fruit Fly ‘Adjacency Matrix’: A neural connectome map of Drosophila’s brain cells, revealing how neurons link up.</br> | • Fruit Fly ‘Adjacency Matrix’: A neural connectome map of Drosophila’s brain cells, revealing how neurons link up.</br> | ||
• Neutrino Telescopes: Huge detectors for elusive cosmic particles, unlocking new views of supernovas & the universe’s earliest moments.</br> | • Neutrino Telescopes: Huge detectors for elusive cosmic particles, unlocking new views of supernovas & the universe’s earliest moments.</br> | ||
• C. elegans Cell Lineage: Tracing every cell from embryo to adult in a tiny worm—vital for developmental biology.</br> | • [[C. elegans]] Cell Lineage: Tracing every cell from embryo to adult in a tiny worm—vital for developmental biology.</br> | ||
• Topological Modular Forms: Abstract math bridging geometry and number theory, hinting at deep universal structures.</br> | • Topological Modular Forms: Abstract math bridging geometry and number theory, hinting at deep universal structures.</br> | ||
• Geometric Langlands: A unifying theory in advanced math linking algebra, geometry, and representations, with implications across physics. | • Geometric Langlands: A unifying theory in advanced math linking algebra, geometry, and representations, with implications across physics. | ||
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Adjacency matrix of drosophila.</br> | Adjacency matrix of drosophila.</br> | ||
Neutrino telescopes</br> | Neutrino telescopes</br> | ||
Cell lineage diagram of [[C | Cell lineage diagram of [[C. elegans|c elegans]]</br> | ||
Topological modular forms</br> | Topological modular forms</br> | ||
Geometric Langlands progress | Geometric Langlands progress | ||
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{{#widget:YouTube|id=PwZ-QuWijc8}} | {{#widget:YouTube|id=PwZ-QuWijc8}} | ||
Eric on Lex Fridman's Podcast mentioning C. elegans in the context of Artificial General Intelligence (AGI) | Eric on Lex Fridman's Podcast mentioning [[C. elegans]] in the context of Artificial General Intelligence (AGI) | ||
{{#widget:YouTube|id=2wq9x2QcZN0|start=2181}} | {{#widget:YouTube|id=2wq9x2QcZN0|start=2181}} | ||