Talk:19: Bret Weinstein - The Prediction and the DISC: Difference between revisions
Talk:19: Bret Weinstein - The Prediction and the DISC (edit)
Revision as of 07:45, 9 August 2020
, 9 August 2020Note curios, post-JRE1494 Jax blog post
(Suggesting addition of tests to validate Bret's hypothesis on the 'remaining questions' section.) |
(Note curios, post-JRE1494 Jax blog post) |
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8) Does experimentally reducing telomere length (e.g. by inhibiting the expression of telomerase) rescue the 'wild type' phenotypes of reduced tolerance to toxins and higher resistance to tumours? | 8) Does experimentally reducing telomere length (e.g. by inhibiting the expression of telomerase) rescue the 'wild type' phenotypes of reduced tolerance to toxins and higher resistance to tumours? | ||
=== Jax Lab on "Telomere length in mice" in July 2020 === | |||
There seems to be only [https://www.jax.org/news-and-insights that one "News and Insights" post about this topic since the ep19] aired, so we might consider is somewhat as a rebuttal, esp. because the JRE episode aired in mid-June. Curios wording [https://archive.is/XhgYI there] (bold by me): | |||
''… '''Greider … observed''' more than 20 years ago that telomeres in some inbred mouse strains are significantly longer than they are in some wild species. The data indicated that '''telomere length isn’t a major factor in determining how long the mice live'''. But '''some researchers''' inferred that inbred laboratory strains, because of their controlled breeding regimens and other factors, had '''developed longer telomeres''' over time. If true, that inference had the potential to skew cancer and aging research data and the quality of the drugs and therapies ultimately produced based on mouse experiments.'' | |||
''How do you know the assumptions are wrong?'' | |||
''… Length is not determined by whether a mouse is inbred or wild-derived, and it is not affected by how long an inbred strain has been domesticated. … as Greider hypothesized 20 years ago, '''telomere length does not predict lifespan'''.'' | |||
Am I seeing ghosts here, or do they: | |||
# present the details of who "inferred" and who "observed" in the opposite order as presented by the Weinsteins? | |||
# label the "potential to skew … quality of the drugs" as a wrong assumption, without clear arguments (or links to data)? | |||
# end their line of argument by taking down a strawman? | |||
# lead the reader into a longevity and cancer discussion, away from the Weinsteins' (IMHO more important argument) "mice models underestimate chronic drug toxicity" argument? | |||